A two-day gathering to transform healthspan medicine, led by the visionaries charting the future of longevity, precision therapeutics, and human potential.
A small, world-class faculty with deep expertise will moderate, guide, and connect the dots across sessions.
A first look at the researchers and clinical leaders anchoring the program — and the work each of them is known for.
Day 2 · Morning
Showed that the ketone body β-hydroxybutyrate blocks HDACs — a molecular link between fasting, metabolism, and aging.
President and CEO of the Buck Institute for Research on Aging, the first independent institute devoted solely to aging. Author of more than 270 papers on how metabolism and diet regulate sirtuins, HDACs, and the aging process.
Keynote
Sets the clinical standard for one of the world’s largest direct-to-consumer health platforms, after five years as Chief Medical Officer of Walgreens.
Global Chief Medical Officer at Hims & Hers (NYSE: HIMS), overseeing clinical care, outcomes, and patient safety across the platform.
Klotho session
Discovered klotho, the aging-suppressor gene — and went on to show that raising it extends lifespan in mice.
Professor in the Division of Anti-Aging Medicine at Jichi Medical University’s Center for Molecular Medicine, where his lab studies the FGF23–klotho system linking phosphate metabolism, kidney disease, and accelerated aging.
Hormones panel
Founded Yale’s first center for women’s health, then built one of America’s earliest precision-medicine longevity practices.
Endocrinologist and founder of the Comite Center for Precision Medicine & Healthy Longevity in New York. Trained at the NIH, with 25 years on the Yale School of Medicine faculty.
Photo: Nick Coleman, Coleman Photo/Graphix · CC BY 4.0We design for outcomes, not applause. Every attendee receives:
A one-page, prioritized playbook and three curated introductions with context, plus 30/60-day follow-ups from our Outcomes Desk.
View sample blueprint →For builders: an agent map, data schema, or protocol outline directly from our AI and technology workshops—ready to ship the following week.
View sample prototype →Japan is the world's most rapidly aging nation, offering a preview of the demographic and healthcare challenges all societies will face. At the same time, it holds some of the deepest cultural roots of longevity.
Nakanoshima Qross · 未来医療国際拠点
Every session is crafted with intention—designed to deliver actionable insights and concrete strategies.
Experience the traditions that have shaped the world's longest-living population.
Begin each day grounded in Japanese tea culture
The science of purpose and living well
Mindfulness through ritual and presence
Japan's kitchen — where food is medicine and tradition
中之島クロス
Japan's government-designated medical innovation hub, established by the Future Medicine Promotion Organization with 21 private enterprises and Osaka Prefecture.
Where regenerative medicine research, clinical practice, and global knowledge exchange converge. Led by pioneering professors with deep connections to Osaka University's regenerative medicine programs.
World-class experts guiding conversations at the intersection of longevity medicine, technology, and global health systems.
Harvard-trained physician and operator across Modern Age and Virta; advisor to leaders at the edge of longevity and AI. Dr. Vinjamoori brings deep expertise in scaling healthspan companies and implementing AI-driven care models.
Physician expert in women's health and regenerative medicine. Medical Director of Precision Medical Care. Scientific Advisor to Muse Cell Innovations, a global leader in stem cell therapeutics, and Vesalius, a leading therapeutics company. Medical Advisor to Eat Real, a national nonprofit transforming school nutrition through evidence-based certification.
Founder reshaping women's health literacy in Japan with background at J&J and Medtronic. Naoko bridges Japanese longevity traditions with modern medical technology, offering unique insights into the world's longest-living population.
Individually confirmed program faculty, led by the researchers and clinical leaders shaping the field.
Showed that the ketone body β-hydroxybutyrate blocks HDACs — a molecular link between fasting, metabolism, and aging.
President and CEO of the Buck Institute for Research on Aging, the first independent institute devoted solely to aging. Author of more than 270 papers on how metabolism and diet regulate sirtuins, HDACs, and the aging process.
Sets the clinical standard for one of the world’s largest direct-to-consumer health platforms, after five years as Chief Medical Officer of Walgreens.
Global Chief Medical Officer at Hims & Hers (NYSE: HIMS), overseeing clinical care, outcomes, and patient safety across the platform.
Discovered klotho, the aging-suppressor gene — and went on to show that raising it extends lifespan in mice.
Professor in the Division of Anti-Aging Medicine at Jichi Medical University’s Center for Molecular Medicine, where his lab studies the FGF23–klotho system linking phosphate metabolism, kidney disease, and accelerated aging.
Founded Yale’s first center for women’s health, then built one of America’s earliest precision-medicine longevity practices.
Endocrinologist and founder of the Comite Center for Precision Medicine & Healthy Longevity in New York. Trained at the NIH, with 25 years on the Yale School of Medicine faculty.
Photo: Nick Coleman, Coleman Photo/Graphix · CC BY 4.0 · cropped and optimized
Principal investigator on the landmark CONFIRM, CREDENCE, and PARADIGM coronary imaging trials, with more than 500 peer-reviewed papers.
Founder and CEO of Cleerly. Formerly Professor of Radiology and Medicine at Weill Cornell Medicine and Director of the Dalio Institute of Cardiovascular Imaging at NewYork-Presbyterian.
Helped develop the first all-spore-based probiotic and ran the human trials that established the category.
Research microbiologist and co-founder of Microbiome Labs, focused on probiotics, intestinal permeability, and the human microbiome.
First to link low blood plasmalogen levels to Alzheimer’s risk — now the basis of a new class of diagnostics.
Neuroscientist and synthetic organic biochemist, and founder of Prodrome Sciences. His work centers on plasmalogens, cell membranes, and the biochemistry that precedes disease.
Co-founded Radiology Partners and built it into the largest physician-led radiology practice in the United States.
Co-founder and President of Radiology Partners, and co-founder of ElaraMD. Previously Chief Information Officer at DaVita.
Founded Boulder Longevity Institute in 2006 and now trains clinicians in cellular medicine through its Human Optimization Academy.
Co-founder and Chief Medical Officer of Boulder Longevity Institute; double board-certified in physical medicine and rehabilitation and in anti-aging and regenerative medicine.
Pioneered the use of epigenetic age testing in life insurance underwriting; previously led global insurance strategy at KPMG.
Founder and CEO of Human Life Expectancy Inc., working at the intersection of epigenetics, insurance, and longevity.
Built Eucalyptus — the group behind Juniper and Pilot — into the telehealth company Hims & Hers acquired for US$1.15 billion.
SVP of International at Hims & Hers; co-founder and former CEO of Eucalyptus, the Australian digital health group.
A leading clinical voice in psychoneuroimmunology — how mind, nervous system, and immunity together shape chronic disease.
Australian-educated physician working across preventive medicine, longevity medicine, and complex multisystem conditions including neurodegeneration.
Built the first causal epigenetic aging clocks, DamAge and AdaptAge — cover work in Nature Aging.
NIH/NIA K00 postdoctoral researcher in aging systems biology at Stanford University and the Institute for Protein Design, and a core member of the Biomarkers of Aging Consortium.
Translates epigenomic and multi-omic data into individual clinical plans through Infinity Epigenetics, the practice he founded in 2023.
Integrative medicine physician in San Francisco, focused on epigenetic health and longevity medicine, and a clinical advisor to biotech teams building longevity assays.
Triple board-certified in cardiology, internal medicine, and functional medicine, with more than 20 years in clinical practice.
Cardiologist and integrative medicine physician in Colorado; Consulting Physician and Scientific Advisor for Hone Health.
Founded Ilara Health to bring diagnostics to Sub-Saharan Africa, and now builds AI-driven longevity clinics across three continents.
Founder and CEO of Expand Health, a global AI-powered longevity clinic network, and co-founder and CEO of Expand Home.
Osaka is Japan's culinary capital and gateway to Kyoto, Nara, and the cultural heart of the country — and, for those who stay on, close enough by Shinkansen to reach Nagano's longevity culture too.
Kansai International Airport (KIX) — direct flights from major US, European, and Asian cities. 50 minutes to central Osaka by express train.
Nakanoshima Qross on Nakanoshima Island — a short walk from major hotels, surrounded by waterfront dining and cultural attractions.
Official Hotel
Hilton Osaka
The conference's official hotel, in Umeda, Osaka's main business and shopping district, a short train ride from Nakanoshima Qross.
Other Recommended Hotels
Luxury 5-star on Nakanoshima Island, walking distance to venue. Stunning skyline views from the 40th floor of Festival Tower West.
4-star hotel near Osaka Castle, approx. 15–20 min walk to venue. Excellent value with Hilton amenities.
Grand heritage hotel on Nakanoshima with 90+ years of tradition, 20 dining venues, and direct rail connection. 10–15 min walk to venue.
For a premium Japanese-style experience: tatami rooms, shoji doors, and traditional futon bedding on the 28th floor with panoramic views.
Booking instructions and the group rate for Hilton Osaka will be sent separately by email closer to the event.
The venue sits adjacent to Kitashinchi, Osaka's premier upscale dining district with over 3,000 restaurants.
“From Green Centenarian To The World”
The Japanese title translates roughly to “Wisdom of Nagano, the City of Longevity.” A two-day, one-night extension built around Nagano, one of Japan's longest-lived regions — where locals have a name for their most vital elders: Green Centenarians.
Nagano City's own numbers explain the name. Local officials attribute the pattern to a handful of interlocking habits: a high-vegetable, fermented, low-salt diet built around sake and miso; a highland climate (roughly 350–400m elevation) with a distinct four seasons; a low-stress culture where nature, faith, and onsen bathing sit close at hand; daily life that keeps people walking and active without a gym; continued social participation among elders; and high rates of preventive checkups and early detection.
Nagano City figures, as of August 2025.
Of Nagano City's roughly 112,000 residents over 65, 233 have already reached their hundredth birthday — enough for locals to have a name for them: Green Centenarians.
By Shinkansen — the Tōkaidō line to Tokyo, then the Hokuriku line north to Nagano.
Depart Osaka by Shinkansen, traveling north into Nagano Prefecture.
An afternoon visit to a local elder-care facility for real dialogue with residents — possibly including a Green Centenarian special guest. This portion is subject to change based on residents' health and infection-control needs.
Settle in ahead of dinner.
Traditional Buddhist vegetarian cuisine — no meat or fish, built from vegetables and tofu, rooted in Zen practice and tuned to natural, seasonal flavor.
O-asaji, the temple's daily dawn service — monks chanting in the half-light — followed by a juzu (prayer bead) blessing.
A healthy morning meal in the same high-vegetable, low-salt pattern behind the city's longevity.
Autumn-foliage viewing at Kagami-ike, then a visit to Togakushi Shrine in the mountains above the city.
Nagano is considered the heartland of Japanese buckwheat noodles, thanks to its pristine water and cool climate — served here with wasabi and traditional condiments.
A traditional foot bath — Nagano's onsen culture, in miniature.
A visit to a sake and miso brewery — both traditional fermented foods made with koji, prized for their umami and the health benefits of fermentation.
The tour concludes; travelers make their own way home from there.
The tour requires a minimum of 9 travelers to run. Registration and payment details will be sent by email to conference attendees after the conference.
We keep admissions intentional so every conversation in Osaka is high quality and highly relevant.
Tell us your role, goals, and what outcomes you want from the event.
Our team evaluates fit and alignment to keep the room high-signal and practical.
Qualified applicants get purchase details, travel planning notes, and onboarding guidance.
Next Generation Longevity 2026 is a curated gathering of leaders shaping the future of healthspan medicine. We review each application to ensure a high-quality experience for all attendees.
The application takes less than 1 minute to complete.
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Open Form in a New TabApplications are reviewed on a rolling basis. Qualified applicants receive an invitation within 5-7 business days.